Mode of Action1

Zinnat (Cefuroxime axetil) is an antibacterial for systemic use. It is a second‐generation cephalosporin.

Zinnat (Cefuroxime axetil) undergoes hydrolysis by esterase enzymes to the active antibiotic, cefuroxime. Zinnat
inhibits bacterial cell wall synthesis following attachment to penicillin binding proteins (PBPs). This results in the
interruption of cell wall (peptidoglycan) biosynthesis, which leads to bacterial cell lysis and death.

Indications1

Zinnat is indicated for the treatment of the infections listed below in adults and children from the age of 3 months.

  • Acute streptococcal tonsillitis and pharyngitis.
  • Acute bacterial sinusitis.
  • Acute otitis media.
  • Acute exacerbations of chronic bronchitis.
  • Cystitis.
  • Pyelonephritis.
  • Uncomplicated skin and soft tissue infections.
  • Treatment of early Lyme disease.

Consideration should be given to official guidance on the appropriate use of antibacterial agents.

Recommended dosage and administration

The usual course of therapy is seven days (range 5 – 10 days).

TABLETS1

Zinnat (Cefuroxime axetil) tablets should ideally be taken after food for optimum absorption.
Available as 250mg or 500mg tablets (pack of 14 tablets).

For Adults and children > 40kg1
Otitis Media 500 mg twice daily
Acute Exacerbations of Chronic Bronchitis 500 mg twice daily
Tonsillopharyngitis 250 mg twice daily
Acute Bacterial Sinusitis 250 mg twice daily
Urinary tract inections and pyelonephritis 250 mg twice daily
Uncomplicated Skin and Soft Tissue Infections 250 mg twice daily
Lyme disease in adults and children over the age of 12 years 500 mg twice daily for 14 days
(range of 10 to 21 days)

SUSPENSION FOR CHILDREN (<40 KG)2

For optimal absorption Zinnat (cefuroxime axetil) suspension should be taken with food,
In infants and children, it may be may be preferable to adjust dosage according to
weight or age. Available as 125mg/5ml or 250mg/5ml x 70ml granules for reconstitution.

If desired, Zinnat Suspension from multidose bottles can be further diluted in cold fruit
juices, or milk drinks and should be taken immediately.

10 mg/kg dosage for most infections1
Age Approximate weight
range (kg)
Dose (mg)
twice daily
No. of measuring spoons
(5 ml) per dose
  125 mg 
250 mg
3 to 6 months 4 to 6 40 to 60 ½
6 months to 2 years 6 to 12 60 to 120 ½ to 1
2 to 12 years 12 to >20 125 1 ½
15 mg/kg dosage for otitis media and more serious infections1
Age Approximate weight
range (kg)
Dose (mg)
twice daily
No. of measuring spoons
(5 ml) per dose
  125 mg 
250 mg
3 to 6 months 4 to 6 60 to 90 ½
6 months to 2 years 6 to 12 90 to 180 1 to 1 ½ ½
2 to 12 years 12 to >20 180 to 250 1 ½ to 2 ½ to 1

There is no experience of using Zinnat in children under the age of 3 months.2

Contraindications1,2

  • Hypersensitivity to cefuroxime or to any of the excipients.
  • Patients with known hypersensitivity to cephalosporin antibiotics.
  • History of severe hypersensitivity (e.g. anaphylactic reaction) to any other type of betalactam antibacterial agent (penicillins, monobactams and carbapenems).

Undesirable effects1,2

The most common adverse reactions are Candida overgrowth, eosinophilia, headache, dizziness, gastrointestinal disturbances and transient rise in liver enzymes.

      For full information, please see the Summary of Product Characteristics.

References:

  1. Zinnat 500 tabs June 2013 SPC
  2. Zinnat 250mg/5ml oral suspension June 2013 SPC.

AB: Last Updated May 2016: MLT_GIB/OTH/0001/15i